Cause Clinical Presentation Diagnosis Prevention Pre-Exposure Prophylaxis (PrEP) – Truvada Taking Options for PrEP When to Take PrEP How to Take PrEP Potential Side Effects and Risks Ongoing Monitoring Needed HIV Management Types of Treatment Failure Contact Tracing Follow-Up HIV PREVENTION at Risk: Contributing Factors HIV Testing Recommendations Prevention advice…

Clinical Presentation Complications Diagnosis of Donovanosis Site/Specimen and Testing Specimen Collection Guidance Investigations Management of Donovanosis Principal Treatment Options Treatment Advice Other Immediate Management Special Treatment Situations Contact Tracing

TYPES OF INFECTION — The clinical designations of genital herpes simplex virus (HSV) infection are: primary, nonprimary first episode, and recurrent: Direct viral test result Type-specific serologic status Classification of genital HSV infection HSV-1 antibodies HSV-2 antibodies HSV-1 detected – – Primary HSV-1 infection – + Nonprimary first episode HSV-1…

Mode of Transmission Incubation Period Infectious Period Clinical Presentation and Outcome Persons at Increased Risk Public Health Significance Symptoms of Gonococcal Infection Complications Diagnosis Specimen Collection and Testing NAATs (Nucleic Acid Amplification Tests): Highly sensitive, allow for self-sampling, and can be used in non-clinical settings. Not validated for non-genital sites,…

Cause Epidemiology: Clinical Presentation Symptoms: Clinical Presentation: Transmission: Complications: Special Considerations: Diagnosis Site/Specimen: Specimen Collection Guidance: Investigations: Management Principal Treatment Option: Treatment Advice: Other Immediate Management: Special Treatment Situations: Contact Tracing Follow-Up Test of Cure: Retesting:

Lumps in the genital skin / mucosa: Genital Ulceration (where the skin is broken or inflamed): uncommonly : Other conditions:  Urethritis (male)/ Non-gonoccocal urethritis (NGU): Epididymo-orchitis  Ano-rectal syndromes (proctitis) Vaginal discharge and cervicitis PID  Ano-genital ulcers  Ano-genital lumps  Genital itch Systemic illness  Key facts and guidelines At risk of STIs?…

(patients who are pregnant, breastfeeding or likely to be nonadherent to doxycycline)

Syphilis Overview Causative Agent: Transmission: Pathogenesis: Stages of Disease General Note: Syphilis can present with central nervous system manifestations (neurosyphilis) at any time during the course of infection. Primary Syphilis (Chancre Stage): Secondary Syphilis: Tertiary Syphilis Overview: Tertiary syphilis describes patients with late syphilis who have symptomatic manifestations involving the…

Risk Factors Consideration: History Taking: Physical Examination: Indications for Asymptomatic STI Testing: Blood Tests: Gonorrhoea and Chlamydia Testing: Notes: Asymptomatic Screening Recommendations: Prevention:

Sample Collection Indications for Testing Mode of Transmission Timeline Clinical Presentation Clinical manifestations of chlamydial infections are difficult to distinguish from gonorrhoea. Symptoms are not necessarily present in all cases. Complications Treatment Follow-up and Contact Tracing Follow-up Care Prevention Strategies for STDs

Overview Anal discharge and pain are typical symptoms of proctitis. Assess risk and investigate sexually transmitted infection (STI) and non-STI causes. STI causes* Patients with STI proctitis are frequently misdiagnosed with non-STI causes (e.g. ulcerative colitis, trauma, radiation proctitis). STIs should be excluded before further investigations are performed (e.g. flexible…