DERMATOLOGY,  PRURITIS

Lichen simplex

  • Lichenification
    1. is a form of dermatitis caused by repeated scratching or rubbing, which results in epidermal thickening 
  • Lichen simplex
    1. due to chronic ‘itch-scratch cycle’ – Starting with an initial itch, chronic scratching and/or rubbing causes further itching, creating a vicious circle.
    2. the trigger of which is unrecognized
      • ie: mosquito, stress, nervous habit etc
    3. following repetitive excoriation and scratching, well circumscribed thickened patches develop
  • inciting stimulus:
    1. Primary lichen simplex develops on normal skin
    2. Secondary lichen simplex can follow an underlying itchy dermatosis
      1. atopic dermatitis, psoriasis, scabies, xerosis
    3. Neural-mediated stimulus that triggers itch
      1. brachioradial pruritus, radiculopathy
    4. Systemic disease associated with pruritus
      1. uraemia, polycythaemia vera, malignancy
    5. Environmental triggers
      1. heat, sweat, chemical irritants, insect bite.
  • Clinically
    1. commonly occurs in mid-late adulthood, with the highest frequency in people aged 30–50 yr,
    2. more in women 2:1 ratio.
    3. demarcated, erythematous patches, and plaques of thickened leathery skin
    4. common in neck / scalp / shoulder / wrist + ankle
    5. Pigmentary changes, such as hyper- or hypopigmentation, are more commonly seen in patients with darker skin types; erythema is much less obvious
  • Differentials
    • Atopic dermatitis
    • Psoriasis
    • Lichen planus
    • Contact dermatitis
    • Mycosis fungoides
    • Superficial basal cell carcinoma, in situ squamous cell carcinoma.
  • Treatment
    1. Breaking the itch-scratch cycle
      1. Physical barriers and bandaging to reduce subconscious scratching
    2. Emollients — aim for use at least twice daily; best applied after showering to retain moisture.
    3. Providing education
    4. Behavioural changes
      1. Reduce stress
      2. keep nails short
      3. wear loose-fitting clothing.
      4. Avoid and/or address trigger
    5. Medications
      1. First-generation sedating antihistamines (e.g. phenhydramine or chlorpheniramine) for those with disruptive night-time pruritus.
      2. Topical corticosteroids — superpotent topical corticosteroids 1–2x daily with either paste bandage or hydrocolloid occlusion(cling wrap) for up to 4 weeks.
        • Weaker steroids can be used in sensitive thin skin areas.
      3. Coal tar preparations.
      4. Topical antipruritics — capsaicin or doxepin cream.
      5. Topical calcineurin inhibitors — tacrolimus ointment or pimecrolimus cream

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