ANXIETY,  PSYCHIATRY

Phobic Disorders

  • Phobia: irrational fear of specific objects, places or situations, or activities
  • the fear is irrational, excessive & disproportionate to actual danger

3 types of phobias:

  • Agoraphobia – fear of being unable to escape a place or situation 
  • social phobia – fear of humiliation or embarrassment in public places
  • specific phobia – isolated phobias

Social phobia

  • A marked or persistent  > 6 months
  • fear of 1/more social or performance situations
    • When exposed to unfamiliar people 
    • Fear of possible scrutiny by others
    • having a conversation
    • meeting unfamiliar people
    • being observed (e.g. – eating or drinking)
    • performing in front of others (e.g. – giving a speech).
  • will act in a way or show anxiety symptoms that will be negatively evaluated (i.e. – will be humiliating or embarrassing: will lead to rejection or offend others).
  • Avoidance
    • Feared social or performance situations are avoide
    • interferes significantly with person’s
      • normal routine
      • occupation fx
      • social activities or relationships
  • Person recognises that the fear is excessive or unreasonable
  • not due to
    • direct effects of a substance
    • general medical condition
    • better accounted for by another mental disorder
  • If individual is < 18yrs, the duration is at least 6 mths
  • Epidemiology:
    • Tends to run in families
  • DDx:
    • Up to 72% of individuals have another psychiatric disorder diagnosis 
    •    Other anxiety disorders
    • Mood disorders
    • Schizoid & avoidant personality disorders
  • Management:
  1. In performance-type social anxiety disorder
    1. beta-blockers have been used for performance anxiety
  2. Cognitive behavioural therapy with exposure
    1. first-line 
    2. gold-standard treatment for social anxiety disorder.
  • 2nd line: pharmacotherapy:
1st line Monotherapy: escitalopram, fluvoxamine, fluvoxamine CR, paroxetine, paroxetine CR, pregabalin, sertraline, venlafaxine XR 
2nd line Monotherapy: alprazolam, bromazepam, citalopram, clonazepam, gabapentin, phenelzine 
3rd line Monotherapy: atomoxetine, bupropion SR, clomipramine, divalproex, duloxetine, fluoxetine, mirtazapine, moclobemide, olanzapine, selegiline, tiagabine, topiramate. 
Adjunctive therapy Aripiprazole, buspirone, paroxetine, risperidone 
Not recommended Monotherapy: atenolol*, buspirone, imipramine, levetiracetam, propranolol*, quetiapine
Adjunctive therapy: clonazepam, pindolol 
  • Beta-blockers
    • have been successfully used in clinical practice for performance situations such as public speaking.
  • Benzodiazepines
    • be used at any time if there is an acute and severe exacerbation of agitation or anxiety in individuals with SAD who do not have co-morbid alcohol or substance abuse. 
    • should be used as a short term solution only  as 1⁄4 of patients with generalized SAD have co-morbid substance use

Agoraphobia

  • fear of being unable to escape a place or situation to such an extent that he/she learns to avoid it
  • fear of being unable to get help in the event of a panic attack
  • Marked fear or anxiety about at least 2 of the following 5 situations:
    • Public transportation (e.g. – automobiles, buses, trains, ships, planes)
    • Open spaces (e.g. – parking lots, malls, marketplaces, bridges)
    • Enclosed places (e.g. – rooms, shops, theatres, cinemas)
    • Crowds or standing in line
    • Being outside of home alone
  • avoids these situations because of thoughts that:
    • Escape might be difficult, or
    • Help might not be available in the event of developing panic-like symptoms or other incapacitating or embarrassing symptoms (e.g. – fear of falling or fear of incontinence in the elderly).
  • the fear, anxiety, or avoidance is persistent, typically lasting for 6 months or more 
  • Beyond the panic attack symptoms (see above), other incapacitating or embarrassing symptoms include symptoms such as:
    • Vomiting and inflammatory bowel symptoms
    • In older adults, a fear of falling
    • In children, a sense of disorientation and getting los
  • Epidemiology
    • F > M
    • chronic lifelong condition
    • attacks fluctuate in frequency, intensity & severity
  • Clinical Presentation:
    • onset: mid 20s (80% < 30 yrs) – but can being at any age
    • usually no precipitating event
    • some pts will report onset after significant life event
    • initial attack – most pts v alarmed → present to ED
    • medical workup – usually –ve
  • panic attack:
    • sudden onset
    • peak within mins
    • last 5 – 30mins
  • Differential Dx:
    • Medical illness
    • angina
    • cardiac arrhythmias
    • congestive heart failure
    • hypoglycaemia
    • hypoxia
    • pulmonary embolism
    • severe pain
    • thyrotoxicosis
    • carcinoid
    • pheochromocytoma
    • Meniere’s diseasd
    • Drugs
      • caffeine
      • sympathomimetic agents e.g. decongestants 
      • psychostimulants & hallucinogens
      • withdrawal – alcohol & benzos
      • thyroid hormones
      • antipsychotic meds
    • Psychiatric illness
      • PTSD
      • SCZ
      • mood disorders
      • personality disorders
      • adjustment disorder with anxious mood
  • Management:
    • Panic attack:
      • relaxation techniques – deep breathing or rebreathing into a paper bag
    • Panic disorder:
      • 1st line – individual psychotherapy
      • CBT
      • distraction & breathing exs
      • help make appropriate attributions to distressing Sx
      • ↑ self-esteem
      • problem solving
      • education re: panic disorder & agoraphobia
    • agoraphobia: Exposure therapy
  • Pharmacotherapy – if CBT is not available or not effective
    • 1st line – SSRIs, Venlafaxine (SNRI)
    • dosages similar to Tx of depression
    • pts should continue meds for at least 6 months – 1 yr to prevent relapse
    • 2nd line – TCAs, benzos, irreversible MAOIs
    • Avoid caffeine

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