- This is a syndrome characterised by glomerulonephritis and respiratory disease together.
- It is driven by a type 2 hypersensitivity reaction whereby IgG anti-basement membrane antibodies attach to the glomerulus to cause glomerulonephritis but can also react with the alveolar membrane to cause pulmonary haemorrhage.
- The three features to remember are:
- Haemoptysis
- Haematuria
- Anaemia
- Treatment is with corticosteroids, but in some cases plasmapheresis to remove autoantibodies has shown great success.
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